Assay Detail
Functional
CHEMBL3300225
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Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation preincubated for 48 hrs measured 24 hrs post [3H]hypoxanthine addition by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.85 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298603 | — | — | 1 | 8.30 |
| CHEMBL191083 | METHYLENE BLUE CATION | 4.0 | 1 | 8.28 |
| CHEMBL1780224 | — | — | 1 | 8.19 |
| CHEMBL3298604 | — | — | 1 | 7.77 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298603 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL191083 | METHYLENE BLUE CATION | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1780224 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3298604 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 198.0 | nM | 6.70 |