Assay Detail
Functional
CHEMBL3300366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human HCA2 receptor expressed in Flp-In-293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins
32
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of (E)-2-(acrylamido)cyclohex-1-enecarboxylic acid derivatives as HCA1, HCA2, and HCA3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Emax | 16 | - | - |
| EC50 | 16 | 5.17 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298702 | — | — | 2 | 6.05 |
| CHEMBL3298701 | — | — | 2 | 5.85 |
| CHEMBL482698 | — | — | 2 | 5.72 |
| CHEMBL3299113 | — | — | 2 | 5.44 |
| CHEMBL3299009 | — | — | 2 | 5.39 |
| CHEMBL3297875 | — | — | 2 | 5.39 |
| CHEMBL3298700 | — | — | 2 | 5.35 |
| CHEMBL3299114 | — | — | 2 | 5.24 |
| CHEMBL3299112 | — | — | 2 | 5.20 |
| CHEMBL3299115 | — | — | 2 | 5.17 |
| CHEMBL484719 | — | — | 2 | 5.08 |
| CHEMBL3298703 | — | — | 2 | 4.90 |
| CHEMBL3297797 | — | — | 2 | 4.58 |
| CHEMBL3299016 | — | — | 2 | 4.56 |
| CHEMBL3297874 | — | — | 2 | 4.44 |
| CHEMBL3297876 | — | — | 2 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298702 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3298701 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL482698 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3299113 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3297875 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3299009 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3298700 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3299114 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3299112 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3299115 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL484719 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3298703 | — | EC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3297797 | — | EC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL3299016 | — | EC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL3297874 | — | EC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL3297876 | — | EC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL3299112 | — | Emax | = | 86.0 | % | - |
| CHEMBL3298701 | — | Emax | = | 96.0 | % | - |
| CHEMBL3299113 | — | Emax | = | 90.0 | % | - |
| CHEMBL3299114 | — | Emax | = | 83.0 | % | - |
| CHEMBL3297875 | — | Emax | = | 91.0 | % | - |
| CHEMBL3299016 | — | Emax | = | 79.0 | % | - |
| CHEMBL484719 | — | Emax | = | 97.0 | % | - |
| CHEMBL3299115 | — | Emax | = | 93.0 | % | - |
| CHEMBL3297874 | — | Emax | = | 82.0 | % | - |
| CHEMBL3299009 | — | Emax | = | 99.0 | % | - |
| CHEMBL482698 | — | Emax | = | 97.0 | % | - |
| CHEMBL3297797 | — | Emax | = | 95.0 | % | - |
| CHEMBL3297876 | — | Emax | = | 85.0 | % | - |
| CHEMBL3298700 | — | Emax | = | 94.0 | % | - |
| CHEMBL3298702 | — | Emax | = | 98.0 | % | - |
| CHEMBL3298703 | — | Emax | = | 96.0 | % | - |