Assay Detail
Binding
CHEMBL3300519
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Inhibition of vitronectin binding to human alphaVbeta3 integrin after 2 hrs by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.42 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 6.70 |
| CHEMBL303561 | — | — | 1 | 5.39 |
| CHEMBL313763 | — | — | 1 | 4.92 |
| CHEMBL3298392 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL303561 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL313763 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3298392 | — | IC50 | = | 21000.0 | nM | 4.68 |