Assay Detail
Binding
CHEMBL3301297
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Inhibition of JAK1 (unknown origin)
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.63 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 8.40 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 8.19 |
| CHEMBL3039513 | DECERNOTINIB | 2.0 | 2 | 7.96 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.82 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3039513 | DECERNOTINIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL3039513 | DECERNOTINIB | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 363.0 | nM | 6.44 |