Assay Detail
Binding
CHEMBL3301302
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Inhibition of chymotrypsin-like activity of rat liver proteasome using fluorogenic substrates for 6 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Acantholactam and pre-neo-kauluamine, manzamine-related alkaloids from the Indonesian marine sponge Acanthostrongylophora ingens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.89 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3299035 | — | — | 1 | 6.89 |
| CHEMBL3299037 | — | — | 1 | 6.47 |
| CHEMBL403233 | MANZAMINE A | — | 1 | 5.70 |
| CHEMBL3299036 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3299035 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3299037 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL403233 | MANZAMINE A | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3299036 | — | IC50 | = | 33000.0 | nM | 4.48 |