Assay Detail
Functional
CHEMBL3301449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells.
400
Total Activities
400
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
MMV Malaria Box screening against Toxoplasma gondii and Entamoeba histolytica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 400 | 4.89 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL579443 | — | — | 1 | 4.97 |
| CHEMBL582666 | — | — | 1 | 4.81 |
| CHEMBL124006 | — | — | 1 | - |
| CHEMBL600305 | — | — | 1 | - |
| CHEMBL526981 | — | — | 1 | - |
| CHEMBL532879 | — | — | 1 | - |
| CHEMBL591637 | — | — | 1 | - |
| CHEMBL588855 | — | — | 1 | - |
| CHEMBL530973 | — | — | 1 | - |
| CHEMBL494669 | — | — | 1 | - |
| CHEMBL546168 | — | — | 1 | - |
| CHEMBL601957 | — | — | 1 | - |
| CHEMBL533563 | — | — | 1 | - |
| CHEMBL547488 | — | — | 1 | - |
| CHEMBL2028051 | — | — | 1 | - |
| CHEMBL581175 | — | — | 1 | - |
| CHEMBL590674 | — | — | 1 | - |
| CHEMBL587410 | — | — | 1 | - |
| CHEMBL529732 | — | — | 1 | - |
| CHEMBL585264 | — | — | 1 | - |
| CHEMBL580580 | — | — | 1 | - |
| CHEMBL587989 | — | — | 1 | - |
| CHEMBL529773 | — | — | 1 | - |
| CHEMBL535730 | — | — | 1 | - |
| CHEMBL2028042 | — | — | 1 | - |
| CHEMBL604323 | — | — | 1 | - |
| CHEMBL535514 | — | — | 1 | - |
| CHEMBL2028053 | — | — | 1 | - |
| CHEMBL592105 | METHYLROSANILINE | -1.0 | 1 | - |
| CHEMBL587288 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL579443 | — | IC50 | = | 10660.0 | nM | 4.97 |
| CHEMBL582666 | — | IC50 | = | 15580.0 | nM | 4.81 |
| CHEMBL582119 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL338094 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL592123 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL585983 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL587485 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL601806 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL601743 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL580516 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL582180 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL534319 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL548209 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL600488 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL585622 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL548374 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL590683 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL600549 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL589422 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL582495 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL579300 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL586178 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL583555 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL525692 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL603686 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL584655 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL579760 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL591623 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL527541 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL601325 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL586078 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL546531 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL598881 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL592550 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL532015 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL602234 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL591887 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL607688 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL589723 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL526800 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL601492 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL547266 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL592808 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL599886 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL584235 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL528437 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL600174 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL601156 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL600356 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL585839 | — | IC50 | > | 30000.0 | nM | - |