Assay Detail
Functional
CHEMBL3301450
Review assay metadata, readout intent, target linkage, and publication context from the same page.
MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate.
400
Total Activities
400
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Toxoplasma gondii |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
MMV Malaria Box screening against Toxoplasma gondii and Entamoeba histolytica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 400 | 4.93 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL585431 | — | — | 1 | 6.72 |
| CHEMBL611070 | — | — | 1 | 5.97 |
| CHEMBL601528 | — | — | 1 | 5.83 |
| CHEMBL49055 | — | — | 1 | 5.52 |
| CHEMBL585622 | — | — | 1 | 5.52 |
| CHEMBL525486 | — | — | 1 | 5.42 |
| CHEMBL586031 | — | — | 1 | 5.34 |
| CHEMBL578933 | — | — | 1 | 5.23 |
| CHEMBL601566 | — | — | 1 | 5.20 |
| CHEMBL590888 | — | — | 1 | 5.19 |
| CHEMBL584015 | — | — | 1 | 5.08 |
| CHEMBL580381 | — | — | 1 | 5.08 |
| CHEMBL546162 | — | — | 1 | 5.06 |
| CHEMBL532525 | — | — | 1 | 4.98 |
| CHEMBL582119 | — | — | 1 | 4.95 |
| CHEMBL589205 | — | — | 1 | 4.89 |
| CHEMBL261095 | — | — | 1 | 4.88 |
| CHEMBL605751 | — | — | 1 | 4.87 |
| CHEMBL532597 | — | — | 1 | 4.86 |
| CHEMBL600444 | — | — | 1 | 4.84 |
| CHEMBL532015 | — | — | 1 | 4.83 |
| CHEMBL602234 | — | — | 1 | 4.75 |
| CHEMBL589946 | — | — | 1 | 4.74 |
| CHEMBL586000 | — | — | 1 | 4.73 |
| CHEMBL589060 | — | — | 1 | 4.72 |
| CHEMBL592550 | — | — | 1 | 4.69 |
| CHEMBL587288 | — | — | 1 | 4.68 |
| CHEMBL586704 | — | — | 1 | 4.68 |
| CHEMBL586468 | — | — | 1 | 4.68 |
| CHEMBL577012 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL585431 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL611070 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL601528 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL585622 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL49055 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL525486 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL586031 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL578933 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL601566 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL590888 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL580381 | — | IC50 | = | 8220.0 | nM | 5.08 |
| CHEMBL584015 | — | IC50 | = | 8230.0 | nM | 5.08 |
| CHEMBL546162 | — | IC50 | = | 8720.0 | nM | 5.06 |
| CHEMBL532525 | — | IC50 | = | 10460.0 | nM | 4.98 |
| CHEMBL582119 | — | IC50 | = | 11160.0 | nM | 4.95 |
| CHEMBL589205 | — | IC50 | = | 12850.0 | nM | 4.89 |
| CHEMBL261095 | — | IC50 | = | 13150.0 | nM | 4.88 |
| CHEMBL605751 | — | IC50 | = | 13480.0 | nM | 4.87 |
| CHEMBL532597 | — | IC50 | = | 13930.0 | nM | 4.86 |
| CHEMBL600444 | — | IC50 | = | 14460.0 | nM | 4.84 |
| CHEMBL532015 | — | IC50 | = | 14920.0 | nM | 4.83 |
| CHEMBL602234 | — | IC50 | = | 17890.0 | nM | 4.75 |
| CHEMBL589946 | — | IC50 | = | 18070.0 | nM | 4.74 |
| CHEMBL586000 | — | IC50 | = | 18660.0 | nM | 4.73 |
| CHEMBL589060 | — | IC50 | = | 19040.0 | nM | 4.72 |
| CHEMBL592550 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL587288 | — | IC50 | = | 20930.0 | nM | 4.68 |
| CHEMBL586704 | — | IC50 | = | 20850.0 | nM | 4.68 |
| CHEMBL586468 | — | IC50 | = | 21060.0 | nM | 4.68 |
| CHEMBL577012 | — | IC50 | = | 21370.0 | nM | 4.67 |
| CHEMBL577011 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL545880 | — | IC50 | = | 24040.0 | nM | 4.62 |
| CHEMBL526800 | — | IC50 | = | 24930.0 | nM | 4.60 |
| CHEMBL124006 | — | IC50 | = | 25840.0 | nM | 4.59 |
| CHEMBL527620 | — | IC50 | = | 25680.0 | nM | 4.59 |
| CHEMBL600904 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL528245 | — | IC50 | = | 26620.0 | nM | 4.58 |
| CHEMBL591393 | — | IC50 | = | 26490.0 | nM | 4.58 |
| CHEMBL607308 | — | IC50 | = | 27050.0 | nM | 4.57 |
| CHEMBL580159 | — | IC50 | = | 26830.0 | nM | 4.57 |
| CHEMBL2028061 | — | IC50 | = | 26750.0 | nM | 4.57 |
| CHEMBL529385 | — | IC50 | = | 28120.0 | nM | 4.55 |
| CHEMBL1623028 | — | IC50 | = | 28990.0 | nM | 4.54 |
| CHEMBL597262 | — | IC50 | = | 28920.0 | nM | 4.54 |
| CHEMBL2028044 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL590201 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL530978 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL600374 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL533999 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL590212 | — | IC50 | > | 30000.0 | nM | - |