Assay Detail
Functional
CHEMBL3301456
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MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. IC50s determined for selected compounds.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
MMV Malaria Box gametocyte functional viability assay screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.38 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL582767 | — | — | 1 | 7.59 |
| CHEMBL530973 | — | — | 1 | 7.35 |
| CHEMBL586031 | — | — | 1 | 7.02 |
| CHEMBL124006 | — | — | 1 | 6.88 |
| CHEMBL602580 | — | — | 1 | 6.86 |
| CHEMBL1437888 | — | — | 1 | 6.74 |
| CHEMBL530223 | — | — | 1 | 6.62 |
| CHEMBL597855 | — | — | 1 | 6.62 |
| CHEMBL581175 | — | — | 1 | 6.54 |
| CHEMBL586310 | — | — | 1 | 6.44 |
| CHEMBL601325 | — | — | 1 | 6.42 |
| CHEMBL549210 | — | — | 1 | 6.32 |
| CHEMBL206540 | — | — | 1 | 6.24 |
| CHEMBL592105 | METHYLROSANILINE | -1.0 | 1 | 6.01 |
| CHEMBL586000 | — | — | 1 | 5.67 |
| CHEMBL1545915 | — | — | 1 | 5.54 |
| CHEMBL524973 | — | — | 1 | 5.49 |
| CHEMBL601378 | — | — | 1 | 5.47 |
| CHEMBL125044 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL582767 | — | IC50 | = | 25.54 | nM | 7.59 |
| CHEMBL530973 | — | IC50 | = | 44.95 | nM | 7.35 |
| CHEMBL586031 | — | IC50 | = | 95.96 | nM | 7.02 |
| CHEMBL124006 | — | IC50 | = | 130.3 | nM | 6.88 |
| CHEMBL602580 | — | IC50 | = | 139.2 | nM | 6.86 |
| CHEMBL1437888 | — | IC50 | = | 182.7 | nM | 6.74 |
| CHEMBL530223 | — | IC50 | = | 240.7 | nM | 6.62 |
| CHEMBL597855 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL581175 | — | IC50 | = | 288.2 | nM | 6.54 |
| CHEMBL586310 | — | IC50 | = | 364.7 | nM | 6.44 |
| CHEMBL601325 | — | IC50 | = | 383.9 | nM | 6.42 |
| CHEMBL549210 | — | IC50 | = | 481.1 | nM | 6.32 |
| CHEMBL206540 | — | IC50 | = | 569.7 | nM | 6.24 |
| CHEMBL592105 | METHYLROSANILINE | IC50 | = | 977.3 | nM | 6.01 |
| CHEMBL586000 | — | IC50 | = | 2136.0 | nM | 5.67 |
| CHEMBL1545915 | — | IC50 | = | 2903.0 | nM | 5.54 |
| CHEMBL524973 | — | IC50 | = | 3241.0 | nM | 5.49 |
| CHEMBL601378 | — | IC50 | = | 3414.0 | nM | 5.47 |
| CHEMBL125044 | — | IC50 | = | 3710.0 | nM | 5.43 |