Assay Detail
Functional
CHEMBL3301457
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MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. IC50s determined for selected compounds.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
MMV Malaria Box gametocyte functional viability assay screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.25 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL582767 | — | — | 1 | 6.80 |
| CHEMBL602580 | — | — | 1 | 6.72 |
| CHEMBL530223 | — | — | 1 | 6.42 |
| CHEMBL592105 | METHYLROSANILINE | -1.0 | 1 | 6.35 |
| CHEMBL1437888 | — | — | 1 | 6.33 |
| CHEMBL601325 | — | — | 1 | 6.21 |
| CHEMBL124006 | — | — | 1 | 5.97 |
| CHEMBL1545915 | — | — | 1 | 5.19 |
| CHEMBL524973 | — | — | 1 | - |
| CHEMBL586031 | — | — | 1 | - |
| CHEMBL601378 | — | — | 1 | - |
| CHEMBL597855 | — | — | 1 | - |
| CHEMBL206540 | — | — | 1 | - |
| CHEMBL581175 | — | — | 1 | - |
| CHEMBL586000 | — | — | 1 | - |
| CHEMBL586310 | — | — | 1 | - |
| CHEMBL530973 | — | — | 1 | - |
| CHEMBL125044 | — | — | 1 | - |
| CHEMBL549210 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL582767 | — | IC50 | = | 159.4 | nM | 6.80 |
| CHEMBL602580 | — | IC50 | = | 188.8 | nM | 6.72 |
| CHEMBL530223 | — | IC50 | = | 383.9 | nM | 6.42 |
| CHEMBL592105 | METHYLROSANILINE | IC50 | = | 445.5 | nM | 6.35 |
| CHEMBL1437888 | — | IC50 | = | 473.1 | nM | 6.33 |
| CHEMBL601325 | — | IC50 | = | 614.1 | nM | 6.21 |
| CHEMBL124006 | — | IC50 | = | 1074.0 | nM | 5.97 |
| CHEMBL1545915 | — | IC50 | = | 6452.0 | nM | 5.19 |
| CHEMBL524973 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL586031 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL601378 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL597855 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL206540 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL581175 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL586000 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL586310 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL530973 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL125044 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL549210 | — | IC50 | > | 50000.0 | nM | - |