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Assay Detail

CHEMBL3301465

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Functional
MMV: Anti-babesial activity assay. Parasite pRBCs at 1% parasitemia were cultivated in 100 ul with 96-well plates at 2.5% and 5% hematocrits. The parasites were cultivated in triplicate for 4 days without replacement of the medium for each concentration of the compound. On the fourth day of culture, lysis buffer containing 2x SGI was added and 50% inhibitory concentration (IC50) values were calculated.
ChEMBL ↗
360
Total Activities
360
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Babesia bovis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

MMV Malaria Box anti-babesial screening.
Igarashi Lab, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 360 5.53 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL533855 — — 1 7.30
CHEMBL532597 — — 1 7.30
CHEMBL592044 — — 1 7.28
CHEMBL1437888 — — 1 7.28
CHEMBL578294 — — 1 7.27
CHEMBL578030 — — 1 7.25
CHEMBL597444 — — 1 7.25
CHEMBL427342 IMIDOCARB 2.0 1 7.23
CHEMBL532141 — — 1 7.23
CHEMBL585686 — — 1 7.23
CHEMBL598279 — — 1 7.22
CHEMBL601786 — — 1 7.22
CHEMBL546799 — — 1 7.22
CHEMBL582478 — — 1 7.21
CHEMBL530308 — — 1 7.20
CHEMBL607688 — — 1 7.17
CHEMBL601534 — — 1 7.17
CHEMBL602586 — — 1 7.17
CHEMBL529874 — — 1 7.16
CHEMBL548469 — — 1 7.15
CHEMBL601814 — — 1 7.14
CHEMBL586933 — — 1 7.11
CHEMBL1616787 — — 1 7.11
CHEMBL582547 — — 1 7.11
CHEMBL588859 — — 1 7.10
CHEMBL602234 — — 1 7.10
CHEMBL1619026 — — 1 7.09
CHEMBL584235 — — 1 7.09
CHEMBL1237255 — — 1 7.09
CHEMBL582552 — — 1 7.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL532597 — IC50 = 50.0 nM 7.30
CHEMBL533855 — IC50 = 50.0 nM 7.30
CHEMBL592044 — IC50 = 52.0 nM 7.28
CHEMBL1437888 — IC50 = 52.0 nM 7.28
CHEMBL578294 — IC50 = 54.0 nM 7.27
CHEMBL597444 — IC50 = 56.0 nM 7.25
CHEMBL578030 — IC50 = 56.0 nM 7.25
CHEMBL427342 IMIDOCARB IC50 = 59.0 nM 7.23
CHEMBL532141 — IC50 = 59.0 nM 7.23
CHEMBL585686 — IC50 = 59.0 nM 7.23
CHEMBL601786 — IC50 = 60.0 nM 7.22
CHEMBL546799 — IC50 = 60.0 nM 7.22
CHEMBL598279 — IC50 = 60.0 nM 7.22
CHEMBL582478 — IC50 = 61.0 nM 7.21
CHEMBL530308 — IC50 = 63.0 nM 7.20
CHEMBL602586 — IC50 = 68.0 nM 7.17
CHEMBL607688 — IC50 = 68.0 nM 7.17
CHEMBL601534 — IC50 = 68.0 nM 7.17
CHEMBL529874 — IC50 = 70.0 nM 7.16
CHEMBL548469 — IC50 = 71.0 nM 7.15
CHEMBL601814 — IC50 = 72.0 nM 7.14
CHEMBL1616787 — IC50 = 77.0 nM 7.11
CHEMBL582547 — IC50 = 78.0 nM 7.11
CHEMBL586933 — IC50 = 78.0 nM 7.11
CHEMBL588859 — IC50 = 80.0 nM 7.10
CHEMBL602234 — IC50 = 80.0 nM 7.10
CHEMBL1237255 — IC50 = 81.0 nM 7.09
CHEMBL584235 — IC50 = 81.0 nM 7.09
CHEMBL1619026 — IC50 = 81.0 nM 7.09
CHEMBL590933 — IC50 = 83.0 nM 7.08
CHEMBL2028063 — IC50 = 83.0 nM 7.08
CHEMBL582552 — IC50 = 83.0 nM 7.08
CHEMBL548209 — IC50 = 86.0 nM 7.07
CHEMBL2028047 — IC50 = 86.0 nM 7.07
CHEMBL609628 — IC50 = 87.0 nM 7.06
CHEMBL590914 — IC50 = 91.0 nM 7.04
CHEMBL606159 — IC50 = 91.0 nM 7.04
CHEMBL532525 — IC50 = 100.0 nM 7.00
CHEMBL524973 — IC50 = 100.0 nM 7.00
CHEMBL548901 — IC50 = 100.0 nM 7.00
CHEMBL579315 — IC50 = 100.0 nM 7.00
CHEMBL606531 — IC50 = 100.0 nM 7.00
CHEMBL534612 — IC50 = 100.0 nM 7.00
CHEMBL581874 — IC50 = 100.0 nM 7.00
CHEMBL529385 — IC50 = 120.0 nM 6.92
CHEMBL547443 — IC50 = 130.0 nM 6.89
CHEMBL582180 — IC50 = 130.0 nM 6.89
CHEMBL528437 — IC50 = 140.0 nM 6.85
CHEMBL577014 — IC50 = 170.0 nM 6.77
CHEMBL599100 — IC50 = 190.0 nM 6.72