Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3301466

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
MMV: Anti-babesial activity assay. Parasite pRBCs at 1% parasitemia were cultivated in 100 ul with 96-well plates at 2.5% and 5% hematocrits. The parasites were cultivated in triplicate for 4 days without replacement of the medium for each concentration of the compound. On the fourth day of culture, lysis buffer containing 2x SGI was added and 50% inhibitory concentration (IC50) values were calculated.
ChEMBL ↗
360
Total Activities
360
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Babesia bigemina
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

MMV Malaria Box anti-babesial screening.
Igarashi Lab, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 360 5.46 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1437888 — — 1 7.48
CHEMBL1237255 — — 1 7.30
CHEMBL547443 — — 1 7.28
CHEMBL529385 — — 1 7.24
CHEMBL609628 — — 1 7.23
CHEMBL582547 — — 1 7.22
CHEMBL578030 — — 1 7.19
CHEMBL529874 — — 1 7.19
CHEMBL2028045 — — 1 7.19
CHEMBL1616787 — — 1 7.18
CHEMBL590914 — — 1 7.17
CHEMBL602586 — — 1 7.17
CHEMBL597444 — — 1 7.17
CHEMBL578294 — — 1 7.17
CHEMBL2028047 — — 1 7.14
CHEMBL584841 — — 1 7.11
CHEMBL546799 — — 1 7.11
CHEMBL586888 — — 1 7.10
CHEMBL546531 — — 1 7.10
CHEMBL592044 — — 1 7.09
CHEMBL579315 — — 1 7.09
CHEMBL548469 — — 1 7.09
CHEMBL532525 — — 1 7.09
CHEMBL585686 — — 1 7.08
CHEMBL600549 — — 1 7.07
CHEMBL530308 — — 1 7.07
CHEMBL579105 — — 1 7.03
CHEMBL588859 — — 1 7.00
CHEMBL592344 — — 1 7.00
CHEMBL602409 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1437888 — IC50 = 33.0 nM 7.48
CHEMBL1237255 — IC50 = 50.0 nM 7.30
CHEMBL547443 — IC50 = 52.0 nM 7.28
CHEMBL529385 — IC50 = 57.0 nM 7.24
CHEMBL609628 — IC50 = 59.0 nM 7.23
CHEMBL582547 — IC50 = 60.0 nM 7.22
CHEMBL2028045 — IC50 = 65.0 nM 7.19
CHEMBL578030 — IC50 = 65.0 nM 7.19
CHEMBL529874 — IC50 = 65.0 nM 7.19
CHEMBL1616787 — IC50 = 66.0 nM 7.18
CHEMBL602586 — IC50 = 68.0 nM 7.17
CHEMBL590914 — IC50 = 68.0 nM 7.17
CHEMBL597444 — IC50 = 68.0 nM 7.17
CHEMBL578294 — IC50 = 67.0 nM 7.17
CHEMBL2028047 — IC50 = 73.0 nM 7.14
CHEMBL546799 — IC50 = 77.0 nM 7.11
CHEMBL584841 — IC50 = 78.0 nM 7.11
CHEMBL546531 — IC50 = 80.0 nM 7.10
CHEMBL586888 — IC50 = 80.0 nM 7.10
CHEMBL532525 — IC50 = 81.0 nM 7.09
CHEMBL548469 — IC50 = 81.0 nM 7.09
CHEMBL592044 — IC50 = 82.0 nM 7.09
CHEMBL579315 — IC50 = 82.0 nM 7.09
CHEMBL585686 — IC50 = 83.0 nM 7.08
CHEMBL530308 — IC50 = 86.0 nM 7.07
CHEMBL600549 — IC50 = 86.0 nM 7.07
CHEMBL579105 — IC50 = 93.0 nM 7.03
CHEMBL606159 — IC50 = 100.0 nM 7.00
CHEMBL2028067 — IC50 = 100.0 nM 7.00
CHEMBL602211 — IC50 = 100.0 nM 7.00
CHEMBL601041 — IC50 = 100.0 nM 7.00
CHEMBL592344 — IC50 = 100.0 nM 7.00
CHEMBL590675 — IC50 = 100.0 nM 7.00
CHEMBL582180 — IC50 = 100.0 nM 7.00
CHEMBL602234 — IC50 = 100.0 nM 7.00
CHEMBL592808 — IC50 = 100.0 nM 7.00
CHEMBL588859 — IC50 = 100.0 nM 7.00
CHEMBL602409 — IC50 = 100.0 nM 7.00
CHEMBL533855 — IC50 = 130.0 nM 6.89
CHEMBL601806 — IC50 = 190.0 nM 6.72
CHEMBL584655 — IC50 = 220.0 nM 6.66
CHEMBL601814 — IC50 = 250.0 nM 6.60
CHEMBL586078 — IC50 = 260.0 nM 6.58
CHEMBL584237 — IC50 = 288.0 nM 6.54
CHEMBL591623 — IC50 = 290.0 nM 6.54
CHEMBL2028063 — IC50 = 320.0 nM 6.50
CHEMBL580140 — IC50 = 360.0 nM 6.44
CHEMBL2028064 — IC50 = 410.0 nM 6.39
CHEMBL532597 — IC50 = 410.0 nM 6.39
CHEMBL527620 — IC50 = 460.0 nM 6.34