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Assay Detail

CHEMBL3301467

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Functional
MMV: Anti-babesial activity assay. Parasite pRBCs at 1% parasitemia were cultivated in 100 ul with 96-well plates at 2.5% and 5% hematocrits. The parasites were cultivated in triplicate for 4 days without replacement of the medium for each concentration of the compound. On the fourth day of culture, lysis buffer containing 2x SGI was added and 50% inhibitory concentration (IC50) values were calculated.
ChEMBL ↗
360
Total Activities
360
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Babesia equi
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

MMV Malaria Box anti-babesial screening.
Igarashi Lab, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 360 5.30 7.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL537071 — — 1 7.29
CHEMBL427342 IMIDOCARB 2.0 1 7.28
CHEMBL529874 — — 1 7.27
CHEMBL602211 — — 1 7.19
CHEMBL524930 — — 1 7.00
CHEMBL602946 — — 1 7.00
CHEMBL1744512 — — 1 7.00
CHEMBL532141 — — 1 7.00
CHEMBL524973 — — 1 7.00
CHEMBL548469 — — 1 7.00
CHEMBL602580 — — 1 6.89
CHEMBL601786 — — 1 6.85
CHEMBL584015 — — 1 6.77
CHEMBL10835 — — 1 6.68
CHEMBL585686 — — 1 6.66
CHEMBL602312 — — 1 6.60
CHEMBL534283 — — 1 6.60
CHEMBL601534 — — 1 6.58
CHEMBL548901 — — 1 6.51
CHEMBL587923 — — 1 6.48
CHEMBL547269 — — 1 6.48
CHEMBL529348 — — 1 6.41
CHEMBL547443 — — 1 6.39
CHEMBL599100 — — 1 6.38
CHEMBL600904 — — 1 6.36
CHEMBL533855 — — 1 6.35
CHEMBL590686 — — 1 6.34
CHEMBL533917 — — 1 6.33
CHEMBL2028064 — — 1 6.33
CHEMBL581187 — — 1 6.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL537071 — IC50 = 51.0 nM 7.29
CHEMBL427342 IMIDOCARB IC50 = 52.0 nM 7.28
CHEMBL529874 — IC50 = 54.0 nM 7.27
CHEMBL602211 — IC50 = 65.0 nM 7.19
CHEMBL548469 — IC50 = 100.0 nM 7.00
CHEMBL602946 — IC50 = 100.0 nM 7.00
CHEMBL524973 — IC50 = 100.0 nM 7.00
CHEMBL532141 — IC50 = 100.0 nM 7.00
CHEMBL1744512 — IC50 = 100.0 nM 7.00
CHEMBL524930 — IC50 = 100.0 nM 7.00
CHEMBL602580 — IC50 = 130.0 nM 6.89
CHEMBL601786 — IC50 = 140.0 nM 6.85
CHEMBL584015 — IC50 = 170.0 nM 6.77
CHEMBL10835 — IC50 = 210.0 nM 6.68
CHEMBL585686 — IC50 = 219.0 nM 6.66
CHEMBL534283 — IC50 = 250.0 nM 6.60
CHEMBL602312 — IC50 = 250.0 nM 6.60
CHEMBL601534 — IC50 = 260.0 nM 6.58
CHEMBL548901 — IC50 = 309.0 nM 6.51
CHEMBL547269 — IC50 = 330.0 nM 6.48
CHEMBL587923 — IC50 = 330.0 nM 6.48
CHEMBL529348 — IC50 = 390.0 nM 6.41
CHEMBL547443 — IC50 = 410.0 nM 6.39
CHEMBL599100 — IC50 = 420.0 nM 6.38
CHEMBL600904 — IC50 = 440.0 nM 6.36
CHEMBL533855 — IC50 = 450.0 nM 6.35
CHEMBL590686 — IC50 = 460.0 nM 6.34
CHEMBL2028064 — IC50 = 470.0 nM 6.33
CHEMBL533917 — IC50 = 470.0 nM 6.33
CHEMBL581187 — IC50 = 480.0 nM 6.32
CHEMBL1437888 — IC50 = 490.0 nM 6.31
CHEMBL534319 — IC50 = 500.0 nM 6.30
CHEMBL590675 — IC50 = 510.0 nM 6.29
CHEMBL2028063 — IC50 = 530.0 nM 6.28
CHEMBL532560 — IC50 = 580.0 nM 6.24
CHEMBL591890 — IC50 = 570.0 nM 6.24
CHEMBL49055 — IC50 = 590.0 nM 6.23
CHEMBL533399 — IC50 = 620.0 nM 6.21
CHEMBL535730 — IC50 = 610.0 nM 6.21
CHEMBL602586 — IC50 = 630.0 nM 6.20
CHEMBL589224 — IC50 = 650.0 nM 6.19
CHEMBL532015 — IC50 = 650.0 nM 6.19
CHEMBL588501 — IC50 = 640.0 nM 6.19
CHEMBL581225 — IC50 = 670.0 nM 6.17
CHEMBL605751 — IC50 = 760.0 nM 6.12
CHEMBL2028068 — IC50 = 760.0 nM 6.12
CHEMBL548209 — IC50 = 800.0 nM 6.10
CHEMBL1623028 — IC50 = 790.0 nM 6.10
CHEMBL584235 — IC50 = 840.0 nM 6.08
CHEMBL591183 — IC50 = 1000.0 nM 6.00