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Assay Detail

CHEMBL3301468

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Functional
MMV: Anti-babesial activity assay. Parasite pRBCs at 1% parasitemia were cultivated in 100 ul with 96-well plates at 2.5% and 5% hematocrits. The parasites were cultivated in triplicate for 4 days without replacement of the medium for each concentration of the compound. On the fourth day of culture, lysis buffer containing 2x SGI was added and 50% inhibitory concentration (IC50) values were calculated.
ChEMBL ↗
360
Total Activities
360
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Babesia caballi
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

MMV Malaria Box anti-babesial screening.
Igarashi Lab, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 360 5.42 7.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL602586 — — 1 7.37
CHEMBL2028044 — — 1 7.17
CHEMBL591890 — — 1 7.16
CHEMBL549216 — — 1 7.16
CHEMBL581187 — — 1 7.15
CHEMBL2028063 — — 1 7.15
CHEMBL591623 — — 1 7.15
CHEMBL591183 — — 1 7.14
CHEMBL2028064 — — 1 7.14
CHEMBL590944 — — 1 7.13
CHEMBL603943 — — 1 7.13
CHEMBL529348 — — 1 7.12
CHEMBL582070 — — 1 7.12
CHEMBL582420 — — 1 7.12
CHEMBL589920 — — 1 7.12
CHEMBL586468 — — 1 7.12
CHEMBL591641 — — 1 7.10
CHEMBL604389 — — 1 7.10
CHEMBL587371 — — 1 7.10
CHEMBL2028057 — — 1 7.10
CHEMBL2028054 — — 1 7.10
CHEMBL427342 IMIDOCARB 2.0 1 7.09
CHEMBL602764 — — 1 7.08
CHEMBL2028043 — — 1 7.05
CHEMBL579105 — — 1 7.00
CHEMBL49055 — — 1 7.00
CHEMBL600488 — — 1 7.00
CHEMBL581860 — — 1 7.00
CHEMBL584829 — — 1 6.96
CHEMBL585686 — — 1 6.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL602586 — IC50 = 43.0 nM 7.37
CHEMBL2028044 — IC50 = 68.0 nM 7.17
CHEMBL549216 — IC50 = 69.0 nM 7.16
CHEMBL591890 — IC50 = 70.0 nM 7.16
CHEMBL591623 — IC50 = 71.0 nM 7.15
CHEMBL581187 — IC50 = 71.0 nM 7.15
CHEMBL2028063 — IC50 = 71.0 nM 7.15
CHEMBL591183 — IC50 = 73.0 nM 7.14
CHEMBL2028064 — IC50 = 73.0 nM 7.14
CHEMBL590944 — IC50 = 74.0 nM 7.13
CHEMBL603943 — IC50 = 74.0 nM 7.13
CHEMBL582070 — IC50 = 76.0 nM 7.12
CHEMBL529348 — IC50 = 76.0 nM 7.12
CHEMBL586468 — IC50 = 76.0 nM 7.12
CHEMBL582420 — IC50 = 75.0 nM 7.12
CHEMBL589920 — IC50 = 76.0 nM 7.12
CHEMBL591641 — IC50 = 80.0 nM 7.10
CHEMBL604389 — IC50 = 80.0 nM 7.10
CHEMBL587371 — IC50 = 80.0 nM 7.10
CHEMBL2028057 — IC50 = 80.0 nM 7.10
CHEMBL2028054 — IC50 = 80.0 nM 7.10
CHEMBL427342 IMIDOCARB IC50 = 81.0 nM 7.09
CHEMBL602764 — IC50 = 83.0 nM 7.08
CHEMBL2028043 — IC50 = 90.0 nM 7.05
CHEMBL581860 — IC50 = 100.0 nM 7.00
CHEMBL579105 — IC50 = 100.0 nM 7.00
CHEMBL49055 — IC50 = 100.0 nM 7.00
CHEMBL600488 — IC50 = 100.0 nM 7.00
CHEMBL584829 — IC50 = 110.0 nM 6.96
CHEMBL600549 — IC50 = 130.0 nM 6.89
CHEMBL585686 — IC50 = 130.0 nM 6.89
CHEMBL586000 — IC50 = 130.0 nM 6.89
CHEMBL598881 — IC50 = 140.0 nM 6.85
CHEMBL585622 — IC50 = 210.0 nM 6.68
CHEMBL529773 — IC50 = 260.0 nM 6.58
CHEMBL532597 — IC50 = 290.0 nM 6.54
CHEMBL532525 — IC50 = 290.0 nM 6.54
CHEMBL601743 — IC50 = 290.0 nM 6.54
CHEMBL586026 — IC50 = 304.0 nM 6.52
CHEMBL584240 — IC50 = 330.0 nM 6.48
CHEMBL602409 — IC50 = 360.0 nM 6.44
CHEMBL533855 — IC50 = 370.0 nM 6.43
CHEMBL584235 — IC50 = 380.0 nM 6.42
CHEMBL602211 — IC50 = 380.0 nM 6.42
CHEMBL2028067 — IC50 = 410.0 nM 6.39
CHEMBL2028068 — IC50 = 410.0 nM 6.39
CHEMBL592044 — IC50 = 440.0 nM 6.36
CHEMBL2028047 — IC50 = 450.0 nM 6.35
CHEMBL548469 — IC50 = 489.0 nM 6.31
CHEMBL579294 — IC50 = 500.0 nM 6.30