Assay Detail
Functional
CHEMBL3301554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
MMV: Modified 3H-Hyoxanthine uptake assay; 1% O2, 5% CO2 in N2.
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
MMV Mararia Box screening against P. falciparum asexual stage parasites under hypoxia and bicarbonate modified culture conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 6.90 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL580353 | — | — | 1 | 8.05 |
| CHEMBL317364 | — | — | 1 | 7.75 |
| CHEMBL587083 | — | — | 1 | 7.64 |
| CHEMBL2028042 | — | — | 1 | 7.33 |
| CHEMBL124006 | — | — | 1 | 7.23 |
| CHEMBL587022 | — | — | 1 | 7.20 |
| CHEMBL601957 | — | — | 1 | 7.19 |
| CHEMBL531290 | — | — | 1 | 7.18 |
| CHEMBL598369 | — | — | 1 | 7.16 |
| CHEMBL106525 | — | — | 1 | 7.12 |
| CHEMBL530973 | — | — | 1 | 7.07 |
| CHEMBL533017 | — | — | 1 | 7.00 |
| CHEMBL494669 | — | — | 1 | 6.88 |
| CHEMBL590674 | — | — | 1 | 6.82 |
| CHEMBL530223 | — | — | 1 | 6.81 |
| CHEMBL547476 | — | — | 1 | 6.77 |
| CHEMBL586704 | — | — | 1 | 6.74 |
| CHEMBL605281 | — | — | 1 | 6.68 |
| CHEMBL602413 | — | — | 1 | 6.66 |
| CHEMBL580580 | — | — | 1 | 6.64 |
| CHEMBL535730 | — | — | 1 | 6.63 |
| CHEMBL2028055 | — | — | 1 | 6.58 |
| CHEMBL549210 | — | — | 1 | 6.55 |
| CHEMBL529773 | — | — | 1 | 6.47 |
| CHEMBL524784 | — | — | 1 | 6.37 |
| CHEMBL525486 | — | — | 1 | 6.30 |
| CHEMBL532987 | — | — | 1 | 6.25 |
| CHEMBL579459 | — | — | 1 | 6.15 |
| CHEMBL534589 | — | — | 1 | - |
| CHEMBL535079 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL580353 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL317364 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL587083 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2028042 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL124006 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL587022 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL601957 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL531290 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL598369 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL106525 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL530973 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL533017 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL494669 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL590674 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL530223 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL547476 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL586704 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL605281 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL602413 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL580580 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL535730 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL2028055 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL549210 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL529773 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL524784 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL525486 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL532987 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL579459 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL601771 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL206540 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL580381 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL587410 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1459149 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL470514 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL582666 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL590888 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL546994 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL587989 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL535514 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL579443 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1615697 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2028053 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL529732 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL605751 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL261693 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL534190 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL585264 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL586344 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL535079 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL534589 | — | IC50 | > | 1000.0 | nM | - |