Assay Detail
Binding
CHEMBL3361464
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Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.08 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3040381 | — | — | 1 | 8.24 |
| CHEMBL407196 | NEUROTENSIN | — | 1 | 7.55 |
| CHEMBL3326831 | — | — | 1 | 6.70 |
| CHEMBL3326832 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3040381 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL407196 | NEUROTENSIN | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL3326831 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL3326832 | — | Ki | = | 1504.0 | nM | 5.82 |