Assay Detail
Binding
CHEMBL3361668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHO-K1 cells by whole cell patch-clamp assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel thienopyrimidinones as mGluR1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.83 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330823 | — | — | 1 | 5.01 |
| CHEMBL3330811 | — | — | 1 | 4.97 |
| CHEMBL1783876 | — | — | 1 | 4.51 |
| CHEMBL3330817 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330823 | — | IC50 | = | 9870.0 | nM | 5.01 |
| CHEMBL3330811 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL1783876 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3330817 | — | IC50 | > | 100000.0 | nM | - |