Assay Detail
Binding
CHEMBL3362087
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Binding affinity to human wild type RORgammat ligand binding domain expressed in Escherichia coli by thermofluor assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
RORγt Modulators Are Potentially Useful for the Treatment of the Immune-Mediated Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 9.15 | 10.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358455 | — | — | 1 | 10.62 |
| CHEMBL3325743 | — | — | 1 | 9.15 |
| CHEMBL3325742 | — | — | 1 | 9.08 |
| CHEMBL3325741 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358455 | — | Kd | = | 0.024 | nM | 10.62 |
| CHEMBL3325743 | — | Kd | = | 0.71 | nM | 9.15 |
| CHEMBL3325742 | — | Kd | = | 0.83 | nM | 9.08 |
| CHEMBL3325741 | — | Kd | = | 18.0 | nM | 7.75 |