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Assay Detail

CHEMBL3362092

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Cryptosporidium IMPDH preincubated for 10 mins before substrate addition by spectrophotometry
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cryptosporidium
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Inosine-5'-monophosphate dehydrogenase (CHEMBL6145)
Type SINGLE PROTEIN
Organism Cryptosporidium parvum

Publication

Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.
Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L.
ACS Med Chem Lett (2014) 5 : 846 -850
PubMed 25147601 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.77 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2348794 1 9.30
CHEMBL2348627 1 9.22
CHEMBL2178644 1 9.00
CHEMBL2348796 1 8.92
CHEMBL2178652 1 8.40
CHEMBL3329562 1 8.05
CHEMBL3329564 1 7.31
CHEMBL3329561 1 6.72
CHEMBL3329563 1 6.48
CHEMBL557281 1 6.16
CHEMBL3329559 1 5.96
CHEMBL564117 1 -
CHEMBL2178638 1 -
CHEMBL2348631 1 -
CHEMBL2348634 1 -
CHEMBL564187 1 -
CHEMBL3329560 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2348794 IC50 = 0.5 nM 9.30
CHEMBL2348627 IC50 = 0.6 nM 9.22
CHEMBL2178644 IC50 = 1.0 nM 9.00
CHEMBL2348796 IC50 = 1.2 nM 8.92
CHEMBL2178652 IC50 = 4.0 nM 8.40
CHEMBL3329562 IC50 = 9.0 nM 8.05
CHEMBL3329564 IC50 = 49.0 nM 7.31
CHEMBL3329561 IC50 = 190.0 nM 6.72
CHEMBL3329563 IC50 = 330.0 nM 6.48
CHEMBL557281 IC50 = 700.0 nM 6.16
CHEMBL3329559 IC50 = 1100.0 nM 5.96
CHEMBL564117 IC50 > 5000.0 nM -
CHEMBL2178638 IC50 > 5000.0 nM -
CHEMBL2348631 IC50 > 5000.0 nM -
CHEMBL2348634 IC50 > 5000.0 nM -
CHEMBL564187 IC50 > 5000.0 nM -
CHEMBL3329560 IC50 > 5000.0 nM -