Assay Detail
Binding
CHEMBL3362097
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Inhibition of partially purified recombinant 5-lipoxygenase (unknown origin) using arachidonic acid as substrate preincubated for 15 mins before substrate addition measured after 10 mins by HPLC analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.43 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318370 | — | — | 1 | 7.52 |
| CHEMBL3318371 | — | — | 1 | 7.52 |
| CHEMBL1076555 | — | — | 1 | 7.52 |
| CHEMBL1081482 | — | — | 1 | 7.52 |
| CHEMBL3318382 | — | — | 1 | 7.30 |
| CHEMBL2023847 | — | — | 1 | 7.30 |
| CHEMBL3318368 | — | — | 1 | 7.22 |
| CHEMBL1081479 | — | — | 1 | 7.22 |
| CHEMBL562493 | — | — | 1 | 7.00 |
| CHEMBL3318381 | — | — | 1 | 6.52 |
| CHEMBL3318369 | — | — | 1 | 6.40 |
| CHEMBL1080391 | — | — | 1 | 6.40 |
| CHEMBL3318373 | — | — | 1 | 6.40 |
| CHEMBL3318379 | — | — | 1 | 6.40 |
| CHEMBL1367191 | — | — | 1 | 6.40 |
| CHEMBL3318380 | — | — | 1 | 6.40 |
| CHEMBL3318383 | — | — | 1 | 6.30 |
| CHEMBL3318378 | — | — | 1 | 6.30 |
| CHEMBL3318374 | — | — | 1 | 6.22 |
| CHEMBL3318384 | — | — | 1 | 6.22 |
| CHEMBL3318377 | — | — | 1 | 6.22 |
| CHEMBL68504 | — | — | 1 | 6.16 |
| CHEMBL3318376 | — | — | 1 | 6.05 |
| CHEMBL1372204 | — | — | 1 | 5.96 |
| CHEMBL1087624 | — | — | 1 | 5.92 |
| CHEMBL3318372 | — | — | 1 | 5.57 |
| CHEMBL3318386 | — | — | 1 | 5.55 |
| CHEMBL554135 | — | — | 1 | 5.43 |
| CHEMBL3318385 | — | — | 1 | 5.17 |
| CHEMBL3318375 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318370 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3318371 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1076555 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1081482 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3318382 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2023847 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3318368 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1081479 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL562493 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3318381 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3318369 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1080391 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3318373 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3318379 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1367191 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3318380 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3318383 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3318378 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3318374 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3318384 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3318377 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL68504 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3318376 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1372204 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1087624 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3318372 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3318386 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL554135 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3318385 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3318375 | — | IC50 | = | 15300.0 | nM | 4.82 |