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Assay Detail

CHEMBL3362141

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-468
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-468 (CHEMBL614335)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues.
He H, Ratnayake AS, Janso JE, He M, Yang HY, Loganzo F, Shor B, O'Donnell CJ, Koehn FE.
J Nat Prod (2014) 77 : 1864 -1870
PubMed 25098528 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 8.55 9.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3326884 1 9.96
CHEMBL3325463 1 8.87
CHEMBL3326878 1 8.81
CHEMBL3326883 1 8.77
CHEMBL3326875 1 8.47
CHEMBL428647 PACLITAXEL 4.0 1 8.14
CHEMBL2333561 THAILANSTATIN A 1 6.85
CHEMBL2333560 THAILANSTATIN B 1 -
CHEMBL3326881 1 -
CHEMBL3326876 1 -
CHEMBL3326877 1 -
CHEMBL3326879 1 -
CHEMBL3326880 1 -
CHEMBL3326882 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3326884 IC50 = 0.11 nM 9.96
CHEMBL3325463 IC50 = 1.35 nM 8.87
CHEMBL3326878 IC50 = 1.56 nM 8.81
CHEMBL3326883 IC50 = 1.7 nM 8.77
CHEMBL3326875 IC50 = 3.4 nM 8.47
CHEMBL428647 PACLITAXEL IC50 = 7.17 nM 8.14
CHEMBL2333561 THAILANSTATIN A IC50 = 142.0 nM 6.85
CHEMBL2333560 THAILANSTATIN B IC50 > 100.0 nM -
CHEMBL3326881 IC50 > 100.0 nM -
CHEMBL3326876 IC50 - -
CHEMBL3326877 IC50 - -
CHEMBL3326879 IC50 - -
CHEMBL3326880 IC50 - -
CHEMBL3326882 IC50 - -