Assay Detail
Binding
CHEMBL3362302
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Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
5-hydroxymethyl-dUMP N-hydrolase (CHEMBL3329079) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 5.49 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3331377 | — | — | 1 | 6.05 |
| CHEMBL3331365 | — | — | 1 | 5.92 |
| CHEMBL3331379 | — | — | 1 | 5.85 |
| CHEMBL3331366 | — | — | 1 | 5.85 |
| CHEMBL3331375 | — | — | 1 | 5.85 |
| CHEMBL3331362 | — | — | 1 | 5.82 |
| CHEMBL3331371 | — | — | 1 | 5.82 |
| CHEMBL3331381 | — | — | 1 | 5.80 |
| CHEMBL3331372 | — | — | 1 | 5.77 |
| CHEMBL519155 | — | — | 1 | 5.75 |
| CHEMBL3331373 | — | — | 1 | 5.75 |
| CHEMBL3356090 | — | — | 1 | 5.64 |
| CHEMBL3331380 | — | — | 1 | 5.52 |
| CHEMBL3331378 | — | — | 1 | 5.41 |
| CHEMBL3331369 | — | — | 1 | 5.38 |
| CHEMBL3331368 | — | — | 1 | 5.35 |
| CHEMBL3331367 | — | — | 1 | 5.32 |
| CHEMBL3329986 | — | — | 1 | 5.28 |
| CHEMBL3331374 | — | — | 1 | 5.23 |
| CHEMBL3331370 | — | — | 1 | 5.13 |
| CHEMBL3331361 | — | — | 1 | 4.97 |
| CHEMBL3331376 | — | — | 1 | 4.92 |
| CHEMBL3331363 | — | — | 1 | 4.92 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 1 | 4.40 |
| CHEMBL3331364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3331377 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL3331365 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3331379 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3331366 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3331375 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3331362 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3331371 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3331381 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3331372 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL519155 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3331373 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3356090 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL3331380 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL3331378 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL3331369 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL3331368 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL3331367 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL3329986 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL3331374 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL3331370 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL3331361 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL3331376 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3331363 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL752 | ADENOSINE PHOSPHATE | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL3331364 | — | Ki | = | 107000.0 | nM | - |