Assay Detail
Binding
CHEMBL3362470
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cryptosporidium |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inosine-5'-monophosphate dehydrogenase (CHEMBL6145) ↗| Type | SINGLE PROTEIN |
| Organism | Cryptosporidium parvum |
Publication
Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.10 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL549612 | — | — | 1 | 8.30 |
| CHEMBL2348823 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL549612 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2348823 | — | Ki | = | 13.0 | nM | 7.89 |