Assay Detail
Binding
CHEMBL3362472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-competitive inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inosine-5'-monophosphate dehydrogenase (CHEMBL3329078) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus anthracis |
Publication
Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.57 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3329562 | — | — | 1 | 8.64 |
| CHEMBL2178617 | — | — | 1 | 8.10 |
| CHEMBL2348823 | — | — | 1 | 7.77 |
| CHEMBL1957258 | — | — | 1 | 7.36 |
| CHEMBL549612 | — | — | 1 | 7.24 |
| CHEMBL2315283 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3329562 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL2178617 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL2348823 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1957258 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL549612 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL2315283 | — | Ki | = | 500.0 | nM | 6.30 |