Assay Detail
Binding
CHEMBL3362602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant MraY overexpressed in Escherichia coli membranes by continuous fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phospho-N-acetylmuramoyl-pentapeptide-transferase (CHEMBL3559642) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
Publication
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.50 | 4.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1205178 | — | — | 1 | 4.50 |
| CHEMBL295292 | MICHELLAMINE A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1205178 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL295292 | MICHELLAMINE A | IC50 | = | 456000.0 | nM | - |