Assay Detail
Binding
CHEMBL3362715
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type HIV1 reverse transcriptase M184V mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation proximity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.89 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3327156 | — | — | 1 | 6.22 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | 6.10 |
| CHEMBL3327153 | — | — | 1 | 5.85 |
| CHEMBL3327158 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3327156 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL666 | FOSCARNET | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3327153 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3327158 | — | IC50 | = | 4200.0 | nM | 5.38 |