Assay Detail
Binding
CHEMBL3362771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat alpha3beta4 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta4 (CHEMBL1907593) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis and Pharmacological Evaluation of DHβE Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.00 | 4.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293950 | — | — | 1 | 4.00 |
| CHEMBL3318897 | — | — | 1 | - |
| CHEMBL3318902 | — | — | 1 | - |
| CHEMBL3318896 | — | — | 1 | - |
| CHEMBL3318892 | — | — | 1 | - |
| CHEMBL3318901 | — | — | 1 | - |
| CHEMBL3318889 | — | — | 1 | - |
| CHEMBL3318893 | — | — | 1 | - |
| CHEMBL3318894 | — | — | 1 | - |
| CHEMBL3318895 | — | — | 1 | - |
| CHEMBL3318890 | — | — | 1 | - |
| CHEMBL3318898 | — | — | 1 | - |
| CHEMBL3318899 | — | — | 1 | - |
| CHEMBL3318900 | — | — | 1 | - |
| CHEMBL3318891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293950 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3318897 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318902 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318896 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318892 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318901 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318889 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318893 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318894 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318895 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318890 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318898 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318899 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318900 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3318891 | — | IC50 | > | 300000.0 | nM | - |