Assay Detail
Binding
CHEMBL3362860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate Con1) |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231) ↗| Type | PROTEIN COMPLEX |
| Organism | Hepatitis C virus |
Publication
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.85 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 9.10 |
| CHEMBL3326826 | — | — | 1 | 8.89 |
| CHEMBL3326830 | — | — | 1 | 8.68 |
| CHEMBL3326539 | — | — | 1 | 8.46 |
| CHEMBL3326829 | — | — | 1 | 8.18 |
| CHEMBL3326540 | — | — | 1 | 7.78 |
| CHEMBL3326538 | — | — | 1 | 7.35 |
| CHEMBL3326537 | — | — | 1 | 6.56 |
| CHEMBL3326536 | — | — | 1 | 5.62 |
| CHEMBL3326827 | — | — | 1 | - |
| CHEMBL3326828 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3326826 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3326830 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3326539 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3326829 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3326540 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL3326538 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3326537 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL3326536 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3326827 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL3326828 | — | IC50 | < | 1000.0 | nM | - |