Assay Detail
Functional
CHEMBL3363103
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Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human Huh7 cells assessed as inhibition of NS4A expression by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.84 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 8.55 |
| CHEMBL3326829 | — | — | 1 | 7.35 |
| CHEMBL3326830 | — | — | 1 | 7.22 |
| CHEMBL3326539 | — | — | 1 | 6.62 |
| CHEMBL3326826 | — | — | 1 | 6.38 |
| CHEMBL3326540 | — | — | 1 | 6.06 |
| CHEMBL3326538 | — | — | 1 | 5.73 |
| CHEMBL3326536 | — | — | 1 | - |
| CHEMBL3326537 | — | — | 1 | - |
| CHEMBL3326827 | — | — | 1 | - |
| CHEMBL3326828 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3326829 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3326830 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3326539 | — | EC50 | = | 242.0 | nM | 6.62 |
| CHEMBL3326826 | — | EC50 | = | 412.5 | nM | 6.38 |
| CHEMBL3326540 | — | EC50 | = | 871.7 | nM | 6.06 |
| CHEMBL3326538 | — | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL3326536 | — | EC50 | - | — | - | |
| CHEMBL3326537 | — | EC50 | - | — | - | |
| CHEMBL3326827 | — | EC50 | < | 750.0 | nM | - |
| CHEMBL3326828 | — | EC50 | < | 750.0 | nM | - |