Assay Detail
Functional
CHEMBL3363134
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Agonist activity at human kappa opioid receptor expressed CHO cells co-expressing Galphaq16 assessed as calcium mobilization by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.19 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | 1.0 | 1 | 8.77 |
| CHEMBL3331545 | — | — | 1 | 5.60 |
| CHEMBL3331546 | — | — | 1 | - |
| CHEMBL3331547 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3331545 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3331546 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3331547 | — | EC50 | > | 10000.0 | nM | - |