Assay Detail
Functional
CHEMBL3363219
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of ABCA1 transcriptional activity in ABCA1p-LUC human HepG2 cells assessed as luciferase activity after 18 hrs
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of Rutaecarpine as ABCA1 Up-Regulator for Treating Atherosclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.71 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3326367 | — | — | 1 | 7.46 |
| CHEMBL1927538 | — | — | 1 | 6.92 |
| CHEMBL1512476 | — | — | 1 | 6.68 |
| CHEMBL552178 | — | — | 1 | 6.15 |
| CHEMBL3326362 | — | — | 1 | 6.09 |
| CHEMBL3326385 | — | — | 1 | 5.89 |
| CHEMBL3326387 | — | — | 1 | 5.81 |
| CHEMBL3326365 | — | — | 1 | 5.78 |
| CHEMBL3326366 | — | — | 1 | 5.48 |
| CHEMBL1491339 | NICOTREDOLE | 2.0 | 1 | 5.43 |
| CHEMBL3326390 | — | — | 1 | 5.20 |
| CHEMBL3326364 | — | — | 1 | 5.18 |
| CHEMBL3326389 | — | — | 1 | 5.05 |
| CHEMBL3326363 | — | — | 1 | 4.97 |
| CHEMBL3326388 | — | — | 1 | 4.71 |
| CHEMBL3326386 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3326367 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1927538 | — | EC50 | = | 121.0 | nM | 6.92 |
| CHEMBL1512476 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL552178 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3326362 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3326385 | — | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3326387 | — | EC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL3326365 | — | EC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL3326366 | — | EC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL1491339 | NICOTREDOLE | EC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL3326390 | — | EC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL3326364 | — | EC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL3326389 | — | EC50 | = | 8860.0 | nM | 5.05 |
| CHEMBL3326363 | — | EC50 | = | 10720.0 | nM | 4.97 |
| CHEMBL3326388 | — | EC50 | = | 19550.0 | nM | 4.71 |
| CHEMBL3326386 | — | EC50 | = | 33240.0 | nM | 4.48 |