Assay Detail
Binding
CHEMBL3363336
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Inhibition of Mer (unknown origin) by Off-chip Mobility Shift Assay
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.00 | 9.24 |
| Ki | 1 | 9.48 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3326002 | — | — | 2 | 9.48 |
| CHEMBL3326004 | — | — | 1 | 9.24 |
| CHEMBL3326006 | — | — | 1 | 9.13 |
| CHEMBL3326007 | — | — | 1 | 8.89 |
| CHEMBL3326005 | — | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3326002 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL3326004 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL3326006 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL3326002 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3326007 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3326005 | — | IC50 | = | 1.6 | nM | 8.80 |