Assay Detail
Binding
CHEMBL3363505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MDM2 (1-188 aa) -p53 (1-83 aa) interaction expressed in Escherichia coli after 18 hrs by HTRF assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Tumour suppressor p53/oncoprotein Mdm2 (CHEMBL1907611) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.44 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3329613 | — | — | 1 | 9.15 |
| CHEMBL2059435 | — | — | 1 | 9.00 |
| CHEMBL3329602 | — | — | 1 | 9.00 |
| CHEMBL3329608 | — | — | 1 | 8.82 |
| CHEMBL3329611 | — | — | 1 | 8.70 |
| CHEMBL3329601 | — | — | 1 | 8.70 |
| CHEMBL3329610 | — | — | 1 | 8.70 |
| CHEMBL3329224 | — | — | 1 | 8.70 |
| CHEMBL3329616 | — | — | 1 | 8.52 |
| CHEMBL3329605 | — | — | 1 | 8.52 |
| CHEMBL2177190 | — | — | 1 | 8.52 |
| CHEMBL3329619 | — | — | 1 | 8.40 |
| CHEMBL3329614 | — | — | 1 | 8.30 |
| CHEMBL3329617 | — | — | 1 | 8.30 |
| CHEMBL3329612 | — | — | 1 | 8.22 |
| CHEMBL3329604 | — | — | 1 | 8.22 |
| CHEMBL3329615 | — | — | 1 | 8.15 |
| CHEMBL3329606 | — | — | 1 | 8.15 |
| CHEMBL3329603 | — | — | 1 | 8.10 |
| CHEMBL3329620 | — | — | 1 | 8.05 |
| CHEMBL3329607 | — | — | 1 | 8.05 |
| CHEMBL3329609 | — | — | 1 | 8.00 |
| CHEMBL3329618 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3329613 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2059435 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3329602 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3329608 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3329611 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3329601 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3329610 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3329224 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3329616 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3329605 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2177190 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3329619 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3329614 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3329617 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3329612 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3329604 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3329615 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3329606 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3329603 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3329620 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3329607 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3329609 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3329618 | — | IC50 | = | 13.0 | nM | 7.89 |