Assay Detail
Binding
CHEMBL3363740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRAF (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.35 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1880739 | GW305074X | — | 1 | 7.97 |
| CHEMBL3309549 | — | — | 1 | 6.73 |
| CHEMBL278041 | SB-202190 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1880739 | GW305074X | IC50 | = | 10.71 | nM | 7.97 |
| CHEMBL3309549 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL278041 | SB-202190 | IC50 | - | — | - |