Assay Detail
Binding
CHEMBL3363845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.36 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.36 |
| CHEMBL3323243 | — | — | 1 | 4.35 |
| CHEMBL364713 | NOSCAPINE | 2.0 | 1 | - |
| CHEMBL3323240 | — | — | 1 | - |
| CHEMBL3323241 | — | — | 1 | - |
| CHEMBL3323242 | — | — | 1 | - |
| CHEMBL3323244 | — | — | 1 | - |
| CHEMBL3323245 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3323243 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL364713 | NOSCAPINE | IC50 | = | 170000.0 | nM | - |
| CHEMBL3323240 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL3323241 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL3323242 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL3323244 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL3323245 | — | IC50 | = | 170000.0 | nM | - |