Assay Detail
Binding
CHEMBL3364002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p53-MDM2 (unknown origin) interaction using 0.2% BSA buffer after 1 hr by HTRF assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Tumour suppressor p53/oncoprotein Mdm2 (CHEMBL1907611) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.80 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3310182 | — | — | 1 | 8.40 |
| CHEMBL3310320 | — | — | 1 | 8.30 |
| CHEMBL3310188 | — | — | 1 | 8.30 |
| CHEMBL3310186 | — | — | 1 | 8.30 |
| CHEMBL3310185 | — | — | 1 | 8.30 |
| CHEMBL3310184 | — | — | 1 | 8.30 |
| CHEMBL3310322 | — | — | 1 | 8.22 |
| CHEMBL3310321 | — | — | 1 | 8.22 |
| CHEMBL3310187 | — | — | 1 | 8.15 |
| CHEMBL3310319 | — | — | 1 | 8.10 |
| CHEMBL2402737 | IDASANUTLIN | 3.0 | 1 | 8.00 |
| CHEMBL3310323 | — | — | 1 | 7.75 |
| CHEMBL3310183 | — | — | 1 | 5.43 |
| CHEMBL3354604 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3310182 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3310320 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310188 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310186 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310185 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310184 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310322 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3310321 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3310187 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3310319 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2402737 | IDASANUTLIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3310323 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3310183 | — | IC50 | = | 3741.0 | nM | 5.43 |
| CHEMBL3354604 | — | IC50 | = | 3900.0 | nM | 5.41 |