Assay Detail
Binding
CHEMBL3364003
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Inhibition of p53-MDM2 (unknown origin) interaction using 0.02% BSA buffer after 1 hr by HTRF assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Tumour suppressor p53/oncoprotein Mdm2 (CHEMBL1907611) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.01 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3310182 | — | — | 1 | 8.40 |
| CHEMBL3310321 | — | — | 1 | 8.30 |
| CHEMBL3310320 | — | — | 1 | 8.30 |
| CHEMBL3310188 | — | — | 1 | 8.30 |
| CHEMBL3310186 | — | — | 1 | 8.30 |
| CHEMBL3310185 | — | — | 1 | 8.30 |
| CHEMBL3310184 | — | — | 1 | 8.30 |
| CHEMBL3310322 | — | — | 1 | 8.22 |
| CHEMBL3310319 | — | — | 1 | 8.15 |
| CHEMBL3310187 | — | — | 1 | 8.15 |
| CHEMBL2402737 | IDASANUTLIN | 3.0 | 1 | 8.05 |
| CHEMBL3310323 | — | — | 1 | 7.82 |
| CHEMBL3310183 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3310182 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3310321 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310320 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310188 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310186 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310185 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310184 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3310322 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3310319 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3310187 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2402737 | IDASANUTLIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3310323 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3310183 | — | IC50 | = | 3089.0 | nM | 5.51 |