Assay Detail
Functional
CHEMBL3364008
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Antiproliferative activity against p53 mutant expressing human MDA-MB-435 cells assessed as inhibition of cell proliferation by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.99 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3310186 | — | — | 1 | 5.16 |
| CHEMBL3310323 | — | — | 1 | 5.03 |
| CHEMBL3310320 | — | — | 1 | 5.02 |
| CHEMBL3310188 | — | — | 1 | 5.00 |
| CHEMBL3310187 | — | — | 1 | 5.00 |
| CHEMBL3310319 | — | — | 1 | 4.97 |
| CHEMBL3310322 | — | — | 1 | 4.96 |
| CHEMBL3310185 | — | — | 1 | 4.94 |
| CHEMBL3310182 | — | — | 1 | 4.94 |
| CHEMBL3310321 | — | — | 1 | 4.92 |
| CHEMBL3310184 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3310186 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL3310323 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3310320 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3310188 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3310187 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3310319 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3310322 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL3310185 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3310182 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL3310321 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3310184 | — | IC50 | = | 12110.0 | nM | 4.92 |