Assay Detail
Binding
CHEMBL3364089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain MAO-A using [14C]-5- hydroxytryptamine creatinine disulphate substrate after 30 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.21 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201142 | RASAGILINE MESYLATE | 4.0 | 1 | 6.38 |
| CHEMBL1200904 | SELEGILINE HYDROCHLORIDE | 4.0 | 1 | 6.03 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201142 | RASAGILINE MESYLATE | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL1200904 | SELEGILINE HYDROCHLORIDE | IC50 | = | 944.0 | nM | 6.03 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 580000.0 | nM | - |