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Assay Detail

CHEMBL3364438

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Binding
Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometry
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Carica papaya
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Papain (CHEMBL4779)
Type SINGLE PROTEIN
Organism Carica papaya

Publication

Influence of azide incorporation on binding affinity by small papain inhibitors.
Wammes AE, Hendriks TG, Amatdjais-Groenen HI, Wijdeven MA, van Hest JC, van Delft FL, Ritschel T, Rutjes FP.
Bioorg Med Chem (2014) 22 : 5593 -5603
PubMed 24972724 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.78 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL200235 1 6.66
CHEMBL3357470 1 6.57
CHEMBL3357955 1 6.55
CHEMBL3357964 1 6.46
CHEMBL371466 1 6.44
CHEMBL3357956 1 6.15
CHEMBL3357957 1 6.01
CHEMBL3357958 1 5.80
CHEMBL3357962 1 5.65
CHEMBL3357468 1 5.64
CHEMBL3357961 1 5.57
CHEMBL3357963 1 5.40
CHEMBL3357965 1 5.22
CHEMBL3357469 1 5.15
CHEMBL3357959 1 4.86
CHEMBL3357960 1 4.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL200235 IC50 = 220.0 nM 6.66
CHEMBL3357470 IC50 = 270.0 nM 6.57
CHEMBL3357955 IC50 = 280.0 nM 6.55
CHEMBL3357964 IC50 = 350.0 nM 6.46
CHEMBL371466 IC50 = 360.0 nM 6.44
CHEMBL3357956 IC50 = 710.0 nM 6.15
CHEMBL3357957 IC50 = 980.0 nM 6.01
CHEMBL3357958 IC50 = 1580.0 nM 5.80
CHEMBL3357962 IC50 = 2250.0 nM 5.65
CHEMBL3357468 IC50 = 2270.0 nM 5.64
CHEMBL3357961 IC50 = 2710.0 nM 5.57
CHEMBL3357963 IC50 = 3970.0 nM 5.40
CHEMBL3357965 IC50 = 5980.0 nM 5.22
CHEMBL3357469 IC50 = 7100.0 nM 5.15
CHEMBL3357959 IC50 = 13900.0 nM 4.86
CHEMBL3357960 IC50 = 51160.0 nM 4.29