Assay Detail
Binding
CHEMBL3364483
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Inhibition of Cdk2 (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.76 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298985 | — | — | 1 | 8.70 |
| CHEMBL3298199 | — | — | 1 | 8.70 |
| CHEMBL3357950 | — | — | 1 | 8.40 |
| CHEMBL3298418 | — | — | 1 | 8.05 |
| CHEMBL3298678 | — | — | 1 | 8.00 |
| CHEMBL3298982 | — | — | 1 | 7.96 |
| CHEMBL3298310 | — | — | 1 | 7.92 |
| CHEMBL3298984 | — | — | 1 | 7.89 |
| CHEMBL3298309 | — | — | 1 | 7.89 |
| CHEMBL3298414 | — | — | 1 | 7.80 |
| CHEMBL3357951 | — | — | 1 | 7.64 |
| CHEMBL3298983 | — | — | 1 | 7.16 |
| CHEMBL3298312 | — | — | 1 | 7.15 |
| CHEMBL3298308 | — | — | 1 | 6.98 |
| CHEMBL3298311 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298985 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3298199 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3357950 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3298418 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3298678 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3298982 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3298310 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3298984 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3298309 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3298414 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3357951 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3298983 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3298312 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3298308 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3298311 | — | IC50 | = | 821.0 | nM | 6.09 |