Assay Detail
Binding
CHEMBL3364547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural manipulation on the catecholic fragment of dopamine D(1) receptor agonist 1-phenyl-N-methyl-benzazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.11 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3325904 | — | — | 1 | 8.35 |
| CHEMBL3325906 | — | — | 1 | 8.00 |
| CHEMBL3325905 | — | — | 1 | 7.99 |
| CHEMBL1193274 | — | — | 1 | 6.88 |
| CHEMBL3325913 | — | — | 1 | 6.79 |
| CHEMBL3325907 | — | — | 1 | 6.72 |
| CHEMBL3325916 | — | — | 1 | 6.08 |
| CHEMBL3325908 | — | — | 1 | 6.06 |
| CHEMBL286080 | SKF-38393 | — | 1 | - |
| CHEMBL3325901 | — | — | 1 | - |
| CHEMBL3325903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3325904 | — | Ki | = | 4.52 | nM | 8.35 |
| CHEMBL3325906 | — | Ki | = | 9.95 | nM | 8.00 |
| CHEMBL3325905 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL1193274 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL3325913 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL3325907 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL3325916 | — | Ki | = | 826.0 | nM | 6.08 |
| CHEMBL3325908 | — | Ki | = | 862.0 | nM | 6.06 |
| CHEMBL286080 | SKF-38393 | Ki | - | — | - | |
| CHEMBL3325901 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3325903 | — | Ki | > | 1000.0 | nM | - |