Assay Detail
Binding
CHEMBL3365098
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Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 mins in presence of 5 mM GSH by HPLC
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.72 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318328 | — | — | 1 | 5.80 |
| CHEMBL3318327 | — | — | 1 | 5.15 |
| CHEMBL3318333 | — | — | 1 | 4.51 |
| CHEMBL3318330 | — | — | 1 | 4.15 |
| CHEMBL3318332 | — | — | 1 | 4.00 |
| CHEMBL1562612 | — | — | 1 | - |
| CHEMBL3318329 | — | — | 1 | - |
| CHEMBL489102 | — | — | 1 | - |
| CHEMBL3318331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318328 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3318327 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3318333 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3318330 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL3318332 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1562612 | — | IC50 | - | — | - | |
| CHEMBL3318329 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL489102 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL3318331 | — | IC50 | - | — | - |