Assay Detail
Binding
CHEMBL3365101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase in human PMNL using arachidonic acid as substrate preincubated for 15 mins before substrate addition measured after 10 mins
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.53 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562493 | — | — | 1 | 6.52 |
| CHEMBL3318370 | — | — | 1 | 6.22 |
| CHEMBL3318368 | — | — | 1 | 6.16 |
| CHEMBL1076555 | — | — | 1 | 6.16 |
| CHEMBL1081482 | — | — | 1 | 6.05 |
| CHEMBL1081479 | — | — | 1 | 6.05 |
| CHEMBL3318371 | — | — | 1 | 6.05 |
| CHEMBL1367191 | — | — | 1 | 5.80 |
| CHEMBL3318378 | — | — | 1 | 5.54 |
| CHEMBL3318381 | — | — | 1 | 5.51 |
| CHEMBL3318383 | — | — | 1 | 5.51 |
| CHEMBL2023847 | — | — | 1 | 5.50 |
| CHEMBL3318379 | — | — | 1 | 5.48 |
| CHEMBL3318384 | — | — | 1 | 5.46 |
| CHEMBL3318369 | — | — | 1 | 5.36 |
| CHEMBL1372204 | — | — | 1 | 5.33 |
| CHEMBL3318385 | — | — | 1 | 5.31 |
| CHEMBL3318380 | — | — | 1 | 5.30 |
| CHEMBL68504 | — | — | 1 | 5.25 |
| CHEMBL1087624 | — | — | 1 | 5.25 |
| CHEMBL3318373 | — | — | 1 | 5.24 |
| CHEMBL3318377 | — | — | 1 | 5.23 |
| CHEMBL3318374 | — | — | 1 | 5.14 |
| CHEMBL554135 | — | — | 1 | 5.08 |
| CHEMBL3318372 | — | — | 1 | 4.65 |
| CHEMBL3318376 | — | — | 1 | 4.63 |
| CHEMBL3318382 | — | — | 1 | - |
| CHEMBL3318375 | — | — | 1 | - |
| CHEMBL1080391 | — | — | 1 | - |
| CHEMBL3318386 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562493 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3318370 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3318368 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1076555 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1081482 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1081479 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3318371 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1367191 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3318378 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3318381 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3318383 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2023847 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3318379 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3318384 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3318369 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1372204 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3318385 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3318380 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL68504 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1087624 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3318373 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3318377 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3318374 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL554135 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3318372 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL3318376 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL3318382 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3318375 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1080391 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3318386 | — | IC50 | > | 30000.0 | nM | - |