Assay Detail
Binding
CHEMBL3365183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Trypanosoma cruzi CYP51 by UV-vis titration method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sterol 14-alpha demethylase (CHEMBL1075110) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi (strain CL Brener) |
Publication
4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 6.96 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3337534 | — | — | 1 | 7.92 |
| CHEMBL3337536 | — | — | 1 | 7.80 |
| CHEMBL3259946 | — | — | 1 | 7.11 |
| CHEMBL3337532 | — | — | 1 | 7.10 |
| CHEMBL3337538 | — | — | 1 | 6.72 |
| CHEMBL3337540 | — | — | 1 | 6.62 |
| CHEMBL3337537 | — | — | 1 | 6.54 |
| CHEMBL3337533 | — | — | 1 | 5.89 |
| CHEMBL507264 | — | — | 1 | - |
| CHEMBL3259944 | — | — | 1 | - |
| CHEMBL3259945 | — | — | 1 | - |
| CHEMBL3337535 | — | — | 1 | - |
| CHEMBL3337539 | — | — | 1 | - |
| CHEMBL3337541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3337534 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL3337536 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL3259946 | — | Kd | = | 77.0 | nM | 7.11 |
| CHEMBL3337532 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL3337538 | — | Kd | = | 190.0 | nM | 6.72 |
| CHEMBL3337540 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL3337537 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL3337533 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL507264 | — | Kd | <= | 10.0 | nM | - |
| CHEMBL3259944 | — | Kd | <= | 10.0 | nM | - |
| CHEMBL3259945 | — | Kd | <= | 10.0 | nM | - |
| CHEMBL3337535 | — | Kd | <= | 10.0 | nM | - |
| CHEMBL3337539 | — | Kd | <= | 10.0 | nM | - |
| CHEMBL3337541 | — | Kd | <= | 10.0 | nM | - |