Assay Detail
Binding
CHEMBL3365241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of alpha4beta2* nAChR low affinity site (unknown origin) expressed in xenopus oocytes by electrophysiology method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.49 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358447 | — | — | 1 | 7.82 |
| CHEMBL3341963 | — | — | 1 | 7.51 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358447 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3341963 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 73.0 | nM | 7.14 |