Assay Detail

CHEMBL3365255

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to human brain alpha3beta4* nAChR

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Tissue	Brain
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.

Yu LF, Zhang HK, Caldarone BJ, Eaton JB, Lukas RJ, Kozikowski AP.
J Med Chem (2014) 57 : 8204 -8223
PubMed 24901260 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.70	10.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL59986	—	—	1	10.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL59986	—	Ki	=	0.02	nM	10.70