Assay Detail
Binding
CHEMBL3365509
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Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.77 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3341794 | — | — | 1 | 7.52 |
| CHEMBL3341944 | — | — | 1 | 7.31 |
| CHEMBL3341943 | — | — | 1 | 6.75 |
| CHEMBL3341945 | — | — | 1 | 6.73 |
| CHEMBL3341787 | — | — | 1 | 6.62 |
| CHEMBL1230714 | — | — | 1 | 6.55 |
| CHEMBL3341947 | — | — | 1 | 6.00 |
| CHEMBL3341951 | — | — | 1 | 5.85 |
| CHEMBL3341952 | — | — | 1 | 5.72 |
| CHEMBL3341789 | — | — | 1 | 5.52 |
| CHEMBL3341792 | — | — | 1 | 5.30 |
| CHEMBL3341946 | — | — | 1 | 5.16 |
| CHEMBL3341948 | — | — | 1 | 4.91 |
| CHEMBL3341949 | — | — | 1 | 4.82 |
| CHEMBL3341953 | — | — | 1 | 4.68 |
| CHEMBL3341791 | — | — | 1 | 4.68 |
| CHEMBL3341793 | — | — | 1 | 4.00 |
| CHEMBL3341790 | — | — | 1 | - |
| CHEMBL3341795 | — | — | 1 | - |
| CHEMBL3341788 | — | — | 1 | - |
| CHEMBL3341955 | — | — | 1 | - |
| CHEMBL3341954 | — | — | 1 | - |
| CHEMBL3341950 | — | — | 1 | - |
| CHEMBL3341942 | — | — | 1 | - |
| CHEMBL3341941 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3341794 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3341944 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3341943 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3341945 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL3341787 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1230714 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3341947 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3341951 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3341952 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL3341789 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3341792 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3341946 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3341948 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL3341949 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3341953 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3341791 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3341793 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL3341790 | — | IC50 | - | — | - | |
| CHEMBL3341795 | — | IC50 | - | — | - | |
| CHEMBL3341788 | — | IC50 | - | — | - | |
| CHEMBL3341955 | — | IC50 | - | — | - | |
| CHEMBL3341954 | — | IC50 | - | — | - | |
| CHEMBL3341950 | — | IC50 | - | — | - | |
| CHEMBL3341942 | — | IC50 | - | — | - | |
| CHEMBL3341941 | — | IC50 | - | — | - |