Assay Detail
Binding
CHEMBL3365517
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Inhibition of BMP2-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | C2C12 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.77 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3341945 | — | — | 1 | 7.80 |
| CHEMBL1230714 | — | — | 1 | 6.64 |
| CHEMBL3341787 | — | — | 1 | 6.62 |
| CHEMBL3341789 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3341945 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1230714 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3341787 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3341789 | — | IC50 | = | 960.0 | nM | 6.02 |