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Assay Detail

CHEMBL3365621

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Functional
Cytotoxicity against human K562 cells by MTT assay
ChEMBL ↗
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Autocuration

Target

K562 (CHEMBL385) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and evaluation of novel alkannin and shikonin oxime derivatives as potent antitumor agents.
Wang R, Zhang X, Song H, Zhou S, Li S.
Bioorg Med Chem Lett (2014) 24 : 4304 -4307
PubMed 25127868 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 42 5.48 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3327385 — — 1 6.16
CHEMBL9470 SHIKONIN — 1 6.16
CHEMBL3327388 — — 1 6.16
CHEMBL3327395 — — 1 5.89
CHEMBL3327394 — — 1 5.89
CHEMBL3327393 — — 1 5.89
CHEMBL28457 ALKANNIN — 1 5.89
CHEMBL3327283 — — 1 5.85
CHEMBL3327291 — — 1 5.82
CHEMBL3327392 — — 1 5.82
CHEMBL3327391 — — 1 5.80
CHEMBL3327397 — — 1 5.77
CHEMBL3327290 — — 1 5.77
CHEMBL3327399 — — 1 5.75
CHEMBL3327289 — — 1 5.72
CHEMBL3327297 — — 1 5.70
CHEMBL3327293 — — 1 5.68
CHEMBL3327396 — — 1 5.68
CHEMBL3327286 — — 1 5.68
CHEMBL3327294 — — 1 5.60
CHEMBL3327295 — — 1 5.58
CHEMBL3327390 — — 1 5.58
CHEMBL3327292 — — 1 5.54
CHEMBL3327387 — — 1 5.52
CHEMBL3327288 — — 1 5.51
CHEMBL3327285 — — 1 5.48
CHEMBL3327398 — — 1 5.44
CHEMBL3327389 — — 1 5.43
CHEMBL3327296 — — 1 5.42
CHEMBL3327386 — — 1 5.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3327385 — IC50 = 700.0 nM 6.16
CHEMBL3327388 — IC50 = 700.0 nM 6.16
CHEMBL9470 SHIKONIN IC50 = 700.0 nM 6.16
CHEMBL3327395 — IC50 = 1300.0 nM 5.89
CHEMBL3327394 — IC50 = 1300.0 nM 5.89
CHEMBL3327393 — IC50 = 1300.0 nM 5.89
CHEMBL28457 ALKANNIN IC50 = 1300.0 nM 5.89
CHEMBL3327283 — IC50 = 1400.0 nM 5.85
CHEMBL3327291 — IC50 = 1500.0 nM 5.82
CHEMBL3327392 — IC50 = 1500.0 nM 5.82
CHEMBL3327391 — IC50 = 1600.0 nM 5.80
CHEMBL3327397 — IC50 = 1700.0 nM 5.77
CHEMBL3327290 — IC50 = 1700.0 nM 5.77
CHEMBL3327399 — IC50 = 1800.0 nM 5.75
CHEMBL3327289 — IC50 = 1900.0 nM 5.72
CHEMBL3327297 — IC50 = 2000.0 nM 5.70
CHEMBL3327293 — IC50 = 2100.0 nM 5.68
CHEMBL3327396 — IC50 = 2100.0 nM 5.68
CHEMBL3327286 — IC50 = 2100.0 nM 5.68
CHEMBL3327294 — IC50 = 2500.0 nM 5.60
CHEMBL3327390 — IC50 = 2600.0 nM 5.58
CHEMBL3327295 — IC50 = 2600.0 nM 5.58
CHEMBL3327292 — IC50 = 2900.0 nM 5.54
CHEMBL3327387 — IC50 = 3000.0 nM 5.52
CHEMBL3327288 — IC50 = 3100.0 nM 5.51
CHEMBL3327285 — IC50 = 3300.0 nM 5.48
CHEMBL3327398 — IC50 = 3600.0 nM 5.44
CHEMBL3327389 — IC50 = 3700.0 nM 5.43
CHEMBL3327296 — IC50 = 3800.0 nM 5.42
CHEMBL3327386 — IC50 = 4700.0 nM 5.33
CHEMBL3327384 — IC50 = 5300.0 nM 5.28
CHEMBL3327287 — IC50 = 5400.0 nM 5.27
CHEMBL3327282 — IC50 = 9300.0 nM 5.03
CHEMBL3327284 — IC50 = 9500.0 nM 5.02
CHEMBL3327383 — IC50 = 12400.0 nM 4.91
CHEMBL3325722 — IC50 = 13500.0 nM 4.87
CHEMBL3327400 — IC50 = 13800.0 nM 4.86
CHEMBL3325720 — IC50 = 14600.0 nM 4.84
CHEMBL3325721 — IC50 = 15400.0 nM 4.81
CHEMBL3327382 — IC50 = 17100.0 nM 4.77
CHEMBL3327381 — IC50 = 21100.0 nM 4.68
CHEMBL3327380 — IC50 = 42700.0 nM 4.37