Assay Detail
Functional
CHEMBL3365964
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Cytotoxicity against human A549 cells after 72 hrs by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.79 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444290 | SIMPLEXIN | — | 1 | 9.52 |
| CHEMBL3309438 | — | — | 1 | 9.40 |
| CHEMBL3741150 | — | — | 1 | 9.15 |
| CHEMBL3309437 | — | — | 1 | 8.57 |
| CHEMBL3309439 | — | — | 1 | 7.62 |
| CHEMBL3309442 | — | — | 1 | 6.56 |
| CHEMBL3309441 | — | — | 1 | 5.82 |
| CHEMBL3309440 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444290 | SIMPLEXIN | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3309438 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3741150 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3309437 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3309439 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3309442 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL3309441 | — | IC50 | = | 1531.0 | nM | 5.82 |
| CHEMBL3309440 | — | IC50 | = | 1951.0 | nM | 5.71 |